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The development of allergen-specific immunotherapy in 1950-1980. Part 13
1961 D.E. Johnstone and L. Crump demonstrated the dose-dependent effect of ASIT by inhaled allergens.

1964 Woerhorst publishes a preliminary report in the little-known East German magazine Allergy and Asthma about Dermatophagoides pteronyssinus - “an allergen producer from house dust.”

1966 A.S.F. Ash and H.O. Shield suggested using the term “H1” for receptors that are blocked by AGP, which were used at that time (hence the term “H1-antagonist”) and were responsible for the narrowing of the blood vessels of the coronary arteries, tachycardia, vascular permeability, pruritus, bronchospasm and rhinorrhea.

1969 The first man on the moon: Neil Armstrong as part of the Apollo 11 mission was the first person to fulfill the dream of mankind, followed by Buzz Aldrin. The US overtakes the Soviet Union in the space race, thereby giving people around the world hope for further space exploration.

1978 K.J. Hunt and his colleagues publish the results of the first controlled trial of immunotherapy using bee venom. Bee venom was more effective than placebo or insect whole body extract.

1980 The pharmaceutical industry provides purified insect venom for diagnosis and immunotherapy.

1982 After several years of development, Philips and Sony create the first CD at a factory in Germany.

1985 Studying T-cells of patients undergoing immunotherapy and patients in the control group, G. Nagaya provides that immunotherapy generates subpopulations of T-cells that are able to suppress the proliferation of T-cells by stimulation with a specific antigen. In the same year, F. Horak and colleagues from the University Hospital in Vienna are developing methods for using allergen chambers in allergology.

1989 WHO and the International Immunotherapy Community published a memorandum on the status of ASIT.

1989 The birth of the World Wide Web - English programmer Timothy Berners, wanting to share scientific information with a team of researchers in the European Laboratory for Particle Physics, near Geneva, Switzerland, invented the Internet.

1993 EAACI issues a memorandum in which sublingual allergy therapy is described as a “promising way.”

1996 A group at Kingston General Hospital, Ontario, Canada, uses an allergenic chamber to investigate the effectiveness of ambrosia pollen immunotherapy.

1997 Memorandum EAACI believes that the use of sublingual ASIT is justified in clinical practice on the basis of established efficacy and favorable safety profile. Play online games on the friv games site with the whole family at http://www.friv2online.com Play online games at the best friv 2 games this website.



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